This paper will look at the dynamics of the foreign policy of Pakistan and its modern relationship with its neighbors including India, Afghanistan, China and Iran. The foreign policy of Pakistan is characterized by the sophisticated relations between securities, diplomatic, and economic, in which the control of conflicts, overcoming cross-border security issues, maintaining strategic alliances, and the development of effective cooperation are the main priorities. In the last ten years, the city of Islamabad has been trying to seek multilateral involvement, economic integration, and trust-building processes to promote long-run stability and regional prosperity. The study demonstrates the influence of geopolitical and domestic security concerns on the Pakistan external activities and the necessity of striking a balance between the security issues and economic diplomacy. This is a critical analysis of the foreign policy of Pakistan in the changing position of South and Central Asia, its strategic priorities, and policy changes.