The paper analyzes the fluctuations in Pak-Afghan relations throughout history and impacts of the foreign powers' involvement in their relations. Both have cultural, economic and historical linkages being Muslim and neighbouring countries. Pakistan always tried to strengthen its relations with Afghanistan but the foreign powers' involvement diminishes their mutual trust level. Pak-Afghan relations have never been constant since beginning, although, there are multiple bondage opportunities between them. Afghan President Hamid Karazai once called both states as "Twin Brothers" who do not afford enmity. Terrorism, Durand Line, cross border insurgency and refugee crisis are the main issues between them and both should develop a mechanism to resolve these issues. This mechanism must be too strong that any third country could not interfere. Both should resolve their issues through dialogue and not to blame each other. Bilateral trade and people to people contacts should be increased to enhance their trust.